Structure of PDB 1gvg Chain A

Receptor sequence
>1gvgA (length=315) Species: 1901 (Streptomyces clavuligerus) [Search protein sequence]
TSVDCTAYGPELRALAARLPRTPRADLYAFLDAAHTAAASLPGALATALD
TFNAEGSEDGHLLLRGLPVEADADLPTTPSSTPAPEDRSLLTMEAMLGLV
GRRLGLHTGYRELRSGTVYHDVYPSPGAHHLSSETSETLLEFHTEMAYHR
LQPNYVMLACSRADHERTAATLVASVRKALPLLDERTRARLLDRRMPCCV
DVAFRIAQVKPLYGDADDPFLGYDRELLAPEDPADKEAVAALSKALDEVT
EAVYLEPGDLLIVDNFRTTHARTPFSPRWDGKDRWLHRVYIRTDRNGQLS
GGERAGDVVAFTPRG
3D structure
PDB1gvg Crystal Structure of a Clavaminate Synthase-Fe(II) -2-Oxoglutarate-Substrate-No Complex: Evidence for Metal Centered Rearrangements
ChainA
Resolution1.54 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.21: clavaminate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FE A H144 E146 H279 H143 E145 H270
BS02 AKG A S134 L141 H144 E146 H279 R281 R293 L295 R297 S133 L140 H143 E145 H270 R272 R284 L286 R288
BS03 PCX A L132 S133 S134 H144 E146 D202 D233 E235 R297 L131 S132 S133 H143 E145 D201 D224 E226 R288
BS04 HOA A E146 H279 E145 H270
Gene Ontology
Molecular Function
GO:0005506 iron ion binding
GO:0016491 oxidoreductase activity
GO:0033758 clavaminate synthase activity
GO:0046872 metal ion binding
Biological Process
GO:0017000 antibiotic biosynthetic process
GO:0033050 clavulanic acid biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:1gvg, PDBe:1gvg, PDBj:1gvg
PDBsum1gvg
PubMed12062399
UniProtQ05581|CAS1_STRCL Clavaminate synthase 1 (Gene Name=cs1)

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