Structure of PDB 1gtr Chain A

Receptor sequence

>1gtrA (length=529) Species: 562 (Escherichia coli) [Search protein sequence]

TNFIRQIIDEDLASGKHTTVHTRFPPEPNGYLHIGHAKSICLNFGIAQDY
KGQCNLRFDDTNPVKEDIEYVESIKNDVEWLGFHWSGNVRYSSDYFDQLH
AYAIELINKGLAYVDELTPEQIREYRGTLTQPGKNSPYRDRSVEENLALF
EKMRAGGFEEGKACLRAKIDMASPFIVMRDPVLYRIKFAEHHQTGNKWCI
YPMYDFTHCISDALEGITHSLCTLEFQDNRRLYDWVLDNITIPVHPRQYE
FSRLNLEYTVMSKRKLNLLVTDKHVEGWDDPRMPTISGLRRRGYTAASIR
EFCKRIGVTKQDNTIEMASLESCIREDLNENAPRAMAVIDPVKLVIENYQ
GEGEMVTMPNHPNKPEMGSRQVPFSGEIWIDRADFREEANKQYKRLVLGK
EVRLRNAYVIKAERVEKDAEGNITTIFCTYDADTLGVIHWVSAAHALPVE
IRLYDRLFSVPNPGAADDFLSVINPESLVIKQGFAEPSLKDAVAGKAFQF
EREGYFCLDSRHSTAEKPVFNRTVGLRDT

3D structure

PDB

1gtr Structural basis of anticodon loop recognition by glutaminyl-tRNA synthetase.

Chain

Resolution

2.5 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

6.1.1.18: glutamine--tRNA ligase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	E34 D66 T68 N69 P126 R130 R133 T135 L136 G168 P181 F182 I183 R192 K194 M210 Y211 F233 Q234 D235 R238 I313 T316 K317 Q318 D319 N320 T321 E323 A325 S326 S329 N336 R341 P369 N370 Q399 K401 R402 R410 R412 N413 V455 Q517 E519 R520 R545 T547	E27 D59 T61 N62 P119 R123 R126 T128 L129 G161 P174 F175 I176 R185 K187 M203 Y204 F226 Q227 D228 R231 I306 T309 K310 Q311 D312 N313 T314 E316 A318 S319 S322 N329 R334 P362 N363 Q392 K394 R395 R403 R405 N406 V437 Q499 E501 R502 R527 T529
BS02	ATP	A	F31 P33 N36 G42 H43 T230 R260 L261 K270	F24 P26 N29 G35 H36 T223 R253 L254 K263

Gene Ontology

	Molecular Function
GO:0000166	nucleotide binding
GO:0004812	aminoacyl-tRNA ligase activity
GO:0004819	glutamine-tRNA ligase activity
GO:0005524	ATP binding

	Biological Process
GO:0006412	translation
GO:0006418	tRNA aminoacylation for protein translation
GO:0006424	glutamyl-tRNA aminoacylation
GO:0006425	glutaminyl-tRNA aminoacylation
GO:0043039	tRNA aminoacylation

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:1gtr, PDBe:1gtr, PDBj:1gtr
PDBsum	1gtr
PubMed	1857417
UniProt	P00962\|SYQ_ECOLI Glutamine--tRNA ligase (Gene Name=glnS)

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