Structure of PDB 1gr2 Chain A

Receptor sequence
>1gr2A (length=250) Species: 10116 (Rattus norvegicus) [Search protein sequence]
KTVVVTTILESPYVMMKKMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIV
GDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPF
MSLGISIMIKESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTY
MRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKV
GGNLDSKGYGIATPKGSSLGNAVNLAVLKLNEQGLLDKLKNKWWYDKGEC
3D structure
PDB1gr2 Structure of a glutamate-receptor ligand-binding core in complex with kainate.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KAI A E25 Y73 P101 T103 R108 L154 S158 T159 E209 M212 E10 Y55 P83 T85 R90 L127 S131 T132 E182 M185 BindingDB: EC50=380000nM,Ki=3690nM
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:1gr2, PDBe:1gr2, PDBj:1gr2
PDBsum1gr2
PubMed9804426
UniProtP19491|GRIA2_RAT Glutamate receptor 2 (Gene Name=Gria2)

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