Structure of PDB 1gos Chain A

Receptor sequence
>1gosA (length=497) Species: 9606 (Homo sapiens) [Search protein sequence]
KCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKY
VDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPF
PPVWNPITYLDHNNFWRTMDDMGREIPSDAPWKAPLAEEWDNMTMKELLD
KLCWTESAKQLATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTN
GGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQTRENVLVETLNHE
MYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVYYKE
PFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLA
RLTKEERLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFP
PGILTQYGRVLRQPVDRIYFAGTETATHWSGYMEGAVEAGERAAREILHA
MGKIPEDEIWQSEPESVDVPAQPITTTFLERHLPSVPGLLRLIGLTT
3D structure
PDB1gos Structure of Human Monoamine Oxidase B, a Drug Target for the Treatment of Neurological Disorders
ChainA
Resolution3.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G62 R197 K296
Catalytic site (residue number reindexed from 1) G59 R194 K293
Enzyme Commision number 1.4.3.21: primary-amine oxidase.
1.4.3.4: monoamine oxidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A V10 G11 G12 G13 S15 E34 A35 R36 G41 R42 G57 G58 S59 Y60 V235 I264 Y393 C397 Y398 T426 G434 Y435 M436 A439 V7 G8 G9 G10 S12 E31 A32 R33 G38 R39 G54 G55 S56 Y57 V232 I261 Y390 C394 Y395 T423 G431 Y432 M433 A436
BS02 NYP A L171 C172 Q206 Y398 L168 C169 Q203 Y395
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008131 primary methylamine oxidase activity
GO:0009055 electron transfer activity
GO:0016491 oxidoreductase activity
GO:0042802 identical protein binding
GO:0050660 flavin adenine dinucleotide binding
GO:0052595 aliphatic amine oxidase activity
GO:0097621 monoamine oxidase activity
Biological Process
GO:0009410 response to xenobiotic stimulus
GO:0009636 response to toxic substance
GO:0010044 response to aluminum ion
GO:0010269 response to selenium ion
GO:0014063 negative regulation of serotonin secretion
GO:0019607 phenylethylamine catabolic process
GO:0021762 substantia nigra development
GO:0032496 response to lipopolysaccharide
GO:0042420 dopamine catabolic process
GO:0045471 response to ethanol
GO:0045964 positive regulation of dopamine metabolic process
GO:0048545 response to steroid hormone
GO:0050665 hydrogen peroxide biosynthetic process
GO:0051412 response to corticosterone
Cellular Component
GO:0005739 mitochondrion
GO:0005740 mitochondrial envelope
GO:0005741 mitochondrial outer membrane
GO:0030425 dendrite
GO:0043025 neuronal cell body

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1gos, PDBe:1gos, PDBj:1gos
PDBsum1gos
PubMed11753429
UniProtP27338|AOFB_HUMAN Amine oxidase [flavin-containing] B (Gene Name=MAOB)

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