Structure of PDB 1gl3 Chain A

Receptor sequence
>1gl3A (length=367) Species: 562 (Escherichia coli) [Search protein sequence]
MKNVGFIGWRGMVGSVLMQRMVEERDFDAIRPVFFSTSQLGQAAPSFGGT
TGTLQDAFDLEALKALDIIVTCQGGDYTNEIYPKLRESGWQGYWIDAASS
LRMKDDAIIILDPVNQDVITDGLNNGIRTFVGGNCTVSLMLMSLGGLFAN
DLVDWVSVATYQAASGGGARHMRELLTQMGHLYGHVADELATPSSAILDI
ERKVTTLTRSGELPVDNFGVPLAGSLIPWIDKQLDNGQSREEWKGQAETN
KILNTSSVIPVDGLCVRVGALRCHSQAFTIKLKKDVSIPTVEELLAAHNP
WAKVVPNDREITMRELTPAAVTGTLTTPVGRLRKLNMGPEFLSAFTVGDQ
LLWGAAEPLRRMLRQLA
3D structure
PDB1gl3 Active Site Analysis of the Potential Antimicrobial Target Aspartate Semialdehyde Dehydrogenase.
ChainA
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C135 Q162 R267 H274
Catalytic site (residue number reindexed from 1) C135 Q162 R267 H274
Enzyme Commision number 1.2.1.11: aspartate-semialdehyde dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CYS A C135 Q162 I230 E241 R267 H274 C135 Q162 I230 E241 R267 H274
BS02 NDP A R10 G11 M12 V13 T37 S38 C72 Q73 A98 C135 S165 G166 G168 A169 Q350 A355 R10 G11 M12 V13 T37 S38 C72 Q73 A98 C135 S165 G166 G168 A169 Q350 A355
Gene Ontology
Molecular Function
GO:0004073 aspartate-semialdehyde dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0046983 protein dimerization activity
GO:0050661 NADP binding
GO:0051287 NAD binding
Biological Process
GO:0006520 amino acid metabolic process
GO:0006974 DNA damage response
GO:0008652 amino acid biosynthetic process
GO:0009085 lysine biosynthetic process
GO:0009086 methionine biosynthetic process
GO:0009088 threonine biosynthetic process
GO:0009089 lysine biosynthetic process via diaminopimelate
GO:0009090 homoserine biosynthetic process
GO:0009097 isoleucine biosynthetic process
GO:0019877 diaminopimelate biosynthetic process
GO:0071266 'de novo' L-methionine biosynthetic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1gl3, PDBe:1gl3, PDBj:1gl3
PDBsum1gl3
PubMed11724560
UniProtP0A9Q9|DHAS_ECOLI Aspartate-semialdehyde dehydrogenase (Gene Name=asd)

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