Structure of PDB 1gkp Chain A

Receptor sequence
>1gkpA (length=458) Species: 275 (Thermus sp.) [Search protein sequence]
PLLIKNGEIITADSRYKADIYAEGETITRIGQNLEAPPGTEVIDATGKYV
FPGFIDPHVHIYLPFMATFAKDTHETGSKAALMGGTTTYIEMCCPSRNDD
ALEGYQLWKSKAEGNSYCDYTFHMAVSKFDEKTEGQLREIVADGISSFKI
FLSYKNFFGVDDGEMYQTLRLAKELGVIVTAHCENAELVGRLQQKLLSEG
KTGPEWHEPSRPEAVEAEGTARFATFLETTGATGYVVHLSCKPALDAAMA
AKARGVPIYIESVIPHFLLDKTYAERGGVEAMKYIMSPPLRDKRNQKVLW
DALAQGFIDTVGTDHCPFDTEQKLLGKEAFTAIPNGIPAIEDRVNLLYTY
GVSRGRLDIHRFVDAASTKAAKLFGLFPRKGTIAVGSDADLVVYDPQYRG
TISVKTQHVNNDYNGFEGFEIDGRPSVVTVRGKVAVRDGQFVGEKGWGKL
LRREPMYF
3D structure
PDB1gkp X-Ray Structure of a Dihydropyrimidinase from Thermus Sp. At 1.3 A Resolution
ChainA
Resolution1.295 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.2.2: dihydropyrimidinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A K150 H183 H239 K149 H182 H238
BS02 ZN A H59 H61 K150 D315 H58 H60 K149 D314
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0046872 metal ion binding
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:1gkp, PDBe:1gkp, PDBj:1gkp
PDBsum1gkp
PubMed12079340
UniProtQ7SIE9

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