Structure of PDB 1gg5 Chain A

Receptor sequence

>1gg5A (length=273) Species: 9606 (Homo sapiens) [Search protein sequence]

VGRRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPII
SRKDITGKLKDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQ
FPLQWFGVPAILKGWFERVFIGEFAYTYAAMYDKGPFRSKKAVLSITTGG
SGSMYSLQGIHGDMNVILWPIQSGILHFCGFQVLEPQLTYSIGHTPADAR
IQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMKKEVQDEEKNKK
FGLSVGHHLGKSIPTDNQIKARK

3D structure

PDB

1gg5 Structure-based development of anticancer drugs: complexes of NAD(P)H:quinone oxidoreductase 1 with chemotherapeutic quinones.

Chain

Resolution

2.5 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	G149 Y155 H161
Catalytic site (residue number reindexed from 1)	G149 Y155 H161
Enzyme Commision number	1.6.5.2: NAD(P)H dehydrogenase (quinone).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	FAD	A	H11 S16 F17 N18 A20 P102 L103 Q104 W105 F106 T147 G149 Y155 I192 R200 L204	H11 S16 F17 N18 A20 P102 L103 Q104 W105 F106 T147 G149 Y155 I192 R200 L204
BS02	E09	A	P68 Y126 Y128 F178	P68 Y126 Y128 F178
BS03	FAD	A	Q66 Y67 P68	Q66 Y67 P68
BS04	E09	A	W105 F106 G149 G150 H161	W105 F106 G149 G150 H161

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003955	NAD(P)H dehydrogenase (quinone) activity
GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H
GO:0004784	superoxide dismutase activity
GO:0005515	protein binding
GO:0008753	NADPH dehydrogenase (quinone) activity
GO:0016491	oxidoreductase activity
GO:0042802	identical protein binding
GO:0050136	NADH:ubiquinone reductase (non-electrogenic) activity

	Biological Process
GO:0000209	protein polyubiquitination
GO:0002931	response to ischemia
GO:0006116	NADH oxidation
GO:0006743	ubiquinone metabolic process
GO:0006801	superoxide metabolic process
GO:0006805	xenobiotic metabolic process
GO:0006809	nitric oxide biosynthetic process
GO:0006979	response to oxidative stress
GO:0007271	synaptic transmission, cholinergic
GO:0007584	response to nutrient
GO:0009410	response to xenobiotic stimulus
GO:0009636	response to toxic substance
GO:0009725	response to hormone
GO:0009743	response to carbohydrate
GO:0014070	response to organic cyclic compound
GO:0014075	response to amine
GO:0019430	removal of superoxide radicals
GO:0030163	protein catabolic process
GO:0032355	response to estradiol
GO:0032496	response to lipopolysaccharide
GO:0033574	response to testosterone
GO:0034599	cellular response to oxidative stress
GO:0042177	negative regulation of protein catabolic process
GO:0042360	vitamin E metabolic process
GO:0042373	vitamin K metabolic process
GO:0043066	negative regulation of apoptotic process
GO:0043279	response to alkaloid
GO:0043525	positive regulation of neuron apoptotic process
GO:0045087	innate immune response
GO:0045454	cell redox homeostasis
GO:0045471	response to ethanol
GO:0051602	response to electrical stimulus
GO:0070301	cellular response to hydrogen peroxide
GO:0070995	NADPH oxidation
GO:0071248	cellular response to metal ion
GO:0110076	negative regulation of ferroptosis
GO:1904772	response to tetrachloromethane
GO:1904844	response to L-glutamine
GO:1904880	response to hydrogen sulfide
GO:1905395	response to flavonoid

	Cellular Component
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0030425	dendrite
GO:0043025	neuronal cell body
GO:0045202	synapse

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:1gg5, PDBe:1gg5, PDBj:1gg5
PDBsum	1gg5
PubMed	11587640
UniProt	P15559\|NQO1_HUMAN NAD(P)H dehydrogenase [quinone] 1 (Gene Name=NQO1)

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