Structure of PDB 1ga8 Chain A

Receptor sequence
>1ga8A (length=278) Species: 487 (Neisseria meningitidis) [Search protein sequence]
MDIVFAADDNYAAYLCVAAKSVEAAHPDTEIRFHVLDAGISEANRAAVAA
NLRGGGGNIRFIDVNPEDFAGFPLNIRHISITTYARLKLGEYIADCDKVL
YLDIDVLVRDSLTPLWDTDLGDNWLGASIDLFVERQEGYKQKIGMADGEY
YFNAGVLLINLKKWRRHDIFKMSSEWVEQYKDVMQYQDQDILNGLFKGGV
CYANSRFNFMPTNYAFMASRHTDPLYRDRTNTVMPVAVSHYCGPAKPWHR
DCTAWGAERFTELAGSLTTVPEEWRGKL
3D structure
PDB1ga8 Crystal structure of the retaining galactosyltransferase LgtC from Neisseria meningitidis in complex with donor and acceptor sugar analogs.
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H78 D103 D105 D130 D188 Q189 H244 K250
Catalytic site (residue number reindexed from 1) H78 D103 D105 D130 D188 Q189 H240 K246
Enzyme Commision number 2.4.1.44: lipopolysaccharide 3-alpha-galactosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Z9D A D130 Y186 G247 D130 Y186 G243
BS02 MN A D103 D105 H244 D103 D105 H240
BS03 UPF A A6 A7 D8 Y11 H78 I79 S80 T83 R86 D103 I104 D105 N153 G155 Q187 D188 Q189 H244 C246 G247 K250 A6 A7 D8 Y11 H78 I79 S80 T83 R86 D103 I104 D105 N153 G155 Q187 D188 Q189 H240 C242 G243 K246 MOAD: Ki=2uM
Gene Ontology
Molecular Function
GO:0016740 transferase activity
GO:0016757 glycosyltransferase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:1ga8, PDBe:1ga8, PDBj:1ga8
PDBsum1ga8
PubMed11175908
UniProtQ93EK7

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