Structure of PDB 1g86 Chain A

Receptor sequence
>1g86A (length=141) Species: 9606 (Homo sapiens) [Search protein sequence]
SLLPVPYTEAASLSTGSTVTIKGRPLVCFLNEPYLQVDFHTEMKEESDIV
FHFQVCFGRRVVMNSREYGAWKQQVESKNMPFQDGQEFELSISVLPDKYQ
VMVNGQSSYTFDHRIKPEAVKMVQVWRDISLTKFNVSYLKR
3D structure
PDB1g86 Charcot-Leyden crystal protein (galectin-10) is not a dual function galectin with lysophospholipase activity but binds a lysophospholipase inhibitor in a novel structural fashion.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.1.5: lysophospholipase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NEQ A C29 D85 C28 D84
BS02 NEQ A H53 N65 W72 H52 N64 W71
Gene Ontology
Molecular Function
GO:0004622 lysophospholipase activity
GO:0005515 protein binding
GO:0030246 carbohydrate binding
GO:0042802 identical protein binding
GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process
Biological Process
GO:0002667 regulation of T cell anergy
GO:0002724 regulation of T cell cytokine production
GO:0046006 regulation of activated T cell proliferation
GO:0070231 T cell apoptotic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0062023 collagen-containing extracellular matrix

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Biological Process
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Cellular Component
External links
PDB RCSB:1g86, PDBe:1g86, PDBj:1g86
PDBsum1g86
PubMed11834744
UniProtQ05315|LEG10_HUMAN Galectin-10 (Gene Name=CLC)

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