Structure of PDB 1g55 Chain A

Receptor sequence
>1g55A (length=313) Species: 9606 (Homo sapiens) [Search protein sequence]
EPLRVLELYSGVGGMHHALRESCIPAQVVAAIDVNTVANEVYKYNFPHTQ
LLAKTIEGITLEEFDRLSFDMILMSPPNSFLHILDILPRLQKLPKYILLE
NVKGFEVSSTRDLLIQTIENCGFQYQEFLLSPTSLGIPNSRLRYFLIAKL
QSEPLPFQAPGQVLMEFPKLSVKMLKDFLEDDTDVNQYLLPPKSLLRYAL
LLDIVQPTCRRSVCFTKGYGSYIEGTGSVLQTAEDVQVENIYKSLTNLSQ
EEQITKLLILKLRYFTPKEIANLLGFPPEFGFPEKITVKQRYRLLGNSLN
VHVVAKLIKILYE
3D structure
PDB1g55 Structure of human DNMT2, an enigmatic DNA methyltransferase homolog that displays denaturant-resistant binding to DNA.
ChainA
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E119 R160 R162
Catalytic site (residue number reindexed from 1) E100 R141 R143
Enzyme Commision number 2.1.1.204: tRNA (cytosine(38)-C(5))-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH A Y10 S11 G12 V13 G15 D34 V35 I57 E58 S76 P78 N375 S376 Y9 S10 G11 V12 G14 D33 V34 I56 E57 S75 P77 N297 S298
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:1g55, PDBe:1g55, PDBj:1g55
PDBsum1g55
PubMed11139614
UniProtO14717|TRDMT_HUMAN tRNA (cytosine(38)-C(5))-methyltransferase (Gene Name=TRDMT1)

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