Structure of PDB 1g50 Chain A

Receptor sequence
>1g50A (length=247) Species: 9606 (Homo sapiens) [Search protein sequence]
NSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRE
LVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLL
FAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIIL
LNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQR
LAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLH
3D structure
PDB1g50 Overexpression, Purification, and Crystal Structure of Native ER alpha LBD
ChainA
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EST A E353 L387 R394 F404 H524 L525 E50 L84 R91 F101 H221 L222 PDBbind-CN: -logKd/Ki=6.28,Kd=0.53uM
BindingDB: IC50=1.3nM,Kd=0.2nM,EC50=0.75nM,Ki=0.21nM
External links
PDB RCSB:1g50, PDBe:1g50, PDBj:1g50
PDBsum1g50
PubMed11437591
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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