Structure of PDB 1fxy Chain A

Receptor sequence
>1fxyA (length=228) Species: 9606 (Homo sapiens) [Search protein sequence]
IVGGYNCKDGEVPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRF
KVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITF
RMNVAPASLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQA
KCEASYPGKITSNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDG
CAQKNKPGVYTKVYNYVKWIKNTIAANS
3D structure
PDB1fxy New enzyme lineages by subdomain shuffling.
ChainA
Resolution2.15 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 Q192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H42 D88 Q178 G179 D180 S181 G182
Enzyme Commision number 3.4.21.4: trypsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0G6 A H57 Y99 D189 S190 C191 Q192 G193 S195 S214 W215 G216 G219 H42 Y85 D175 S176 C177 Q178 G179 S181 S196 W197 G198 G200
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1fxy, PDBe:1fxy, PDBj:1fxy
PDBsum1fxy
PubMed9707558
UniProtP07477|TRY1_HUMAN Serine protease 1 (Gene Name=PRSS1)

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