Structure of PDB 1fwx Chain A

Receptor sequence

>1fwxA (length=591) Species: 266 (Paracoccus denitrificans)

ADGSVAPGQLDDYYGFWSSGQSGEMRILGIPSMRELMRVPVFNRCSATGW
GQTNESVRIHERTMSERTKKFLAANGKRIHDNGDLHHVHMSFTEGKYDGR
FLFMNDKANTRVARVRCDVMKCDAILEIPNAKGIHGLRPQKWPRSNYVFC
NGEDETPLVNDGTNMEDVANYVNVFTAVDADKWEVAWQVLVSGNLDNCDA
DYEGKWAFSTSYNSEKGMTLPEMTAAEMDHIVVFNIAEIEKAIAAGDYQE
LNGVKVVDGRKEASSLFTRYIPIANNPHGCNMAPDKKHLCVAGKLSPTVT
VLDVTRFDAVFYENADPRSAVVAEPELGLGPLHTAFDGRGNAYTSLFLDS
QVVKWNIEDAIRAYAGEKVDPIKDKLDVHYQPGHLKTVMGETLDATNDWL
VCLSKFSKDRFLNVGPLKPENDQLIDISGDKMVLVHDGPTFAEPHDAIAV
HPSILSDIKSVWDRNDPMWAETRAQAEADGVDIDNWTEEVIRDGNKVRVY
MSSVAPSFSIESFTVKEGDEVTVIVTNLDEIDDLTHGFTMGNYGVAMEIG
PQMTSSVTFVAANPGVYWYYCQWFCHALHMEMRGRMLVEPK

3D structure

• PDB: 1fwx Revisiting the Catalytic CuZ Cluster of Nitrous Oxide (N2O) Reductase. Evidence of a Bridging Inorganic Sulfur
• Chain: A
• Resolution: 1.6 Å

Enzymatic activity

• Enzyme Commision number: 1.7.2.4: nitrous-oxide reductase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CA	A	Y204 E207 M215 D221 N268	Y212 E215 M223 D229 N276
BS02	CA	A	K397 E412	K405 E420
BS03	CUA	A	H526 C561 W563 C565 H569 M572	H536 C571 W573 C575 H579 M582

Gene Ontology

Molecular Function

• GO:0004129 cytochrome-c oxidase activity
• GO:0005507 copper ion binding
• GO:0005509 calcium ion binding
• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding
• GO:0050304 nitrous-oxide reductase activity

Biological Process

• GO:0019333 denitrification pathway
• GO:1902600 proton transmembrane transport

Cellular Component

• GO:0016020 membrane
• GO:0042597 periplasmic space

External links

• PDB: RCSB:1fwx, PDBe:1fwx, PDBj:1fwx
• PDBsum: 1fwx
• PubMed: 11024061
• UniProt: Q51705|NOSZ_PARDE Nitrous-oxide reductase (Gene Name=nosZ)