Structure of PDB 1fw6 Chain A

Receptor sequence

>1fw6A (length=759) Species: 271 (Thermus aquaticus)

MEGMLKGEGPGPLPPLLQQYVELRDQYPDYLLLFQVGDFYECFGEDAERL
ARALGLVLTHKTSKDFTTPMAGIPLRAFEAYAERLLKMGFRLAVADQVEP
AEEAEGLVRREVTQLLTPGTLLQESLLPREANYLAAIATGDGWGLAFLDV
STGEFKGTVLKSKSALYDELFRHRPAEVLLAPELLENGAFLDEFRKRFPV
MLSEAPFEPEGEGPLALRRARGALLAYAQRTQGGALSLQPFRFYDPGAFM
RLPEATLRALEVFEPLRGQDTLFSVLDETRTAPGRRLLQSWLRHPLLDRG
PLEARLDRVEGFVREGALREGVRRLLYRLADLERLATRLELGRASPKDLG
ALRRSLQILPELRALLGEEVGLPDLSPLKEELEAALVEDPPLKVSEGGLI
REGYDPDLDALRAAHREGVAYFLELEERERERTGIPTLKVGYNAVFGYYL
EVTRPYYERVPKEYRPVQTLKDRQRYTLPEMKEKEREVYRLEALIRRREE
EVFLEVRERAKRQAEALREAARILAELDVYAALAEVAVRYGYVRPRFGDR
LQIRAGRHPVVERRTEFVPNDLEMAHELVLITGPNMAGKSTFLRQTALIA
LLAQVGSFVPAEEAHLPLFDGIYTRIGAGKSTFMVEMEEVALILKEATEN
SLVLLDEVGRGTSSLDGVAIATAVAEALHERRAYTLFATHYFELTALGLP
RLKNLHVAAREEAGGLVFYHQVLPGPASKSYGVEVAAMAGLPKEVVARAR
ALLQAMAAR

3D structure

• PDB: 1fw6 Composite active site of an ABC ATPase: MutS uses ATP to verify mismatch recognition and authorize DNA repair.
• Chain: A
• Resolution: 2.7 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	F39 E41 V57 T59 M70 G72 L470 K471 R473 R475	F39 E41 V57 T59 M70 G72 L470 K471 R473 R475
BS02	dna	A	P14 P15 L16 D38 K64 A101 V108 R110	P14 P15 L16 D38 K64 A101 V108 R110
BS03	ADP	A	F567 V568 N585 M586 A587 G588 K589 S590 T591 H726	F567 V568 N585 M586 A587 G588 K589 S590 T591 H720

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003684 damaged DNA binding
• GO:0003690 double-stranded DNA binding
• GO:0005524 ATP binding
• GO:0030983 mismatched DNA binding
• GO:0140664 ATP-dependent DNA damage sensor activity

Biological Process

• GO:0006281 DNA repair
• GO:0006298 mismatch repair

External links

• PDB: RCSB:1fw6, PDBe:1fw6, PDBj:1fw6
• PDBsum: 1fw6
• PubMed: 11172706
• UniProt: Q56215|MUTS_THEAQ DNA mismatch repair protein MutS (Gene Name=mutS)