Structure of PDB 1fw1 Chain A

Receptor sequence
>1fw1A (length=208) Species: 9606 (Homo sapiens) [Search protein sequence]
KPILYSYFRSSCSWRVRIALALKGIDYKTVPINLIKDGGQQFSKDFQALN
PMKQVPTLKIDGITIHQSLAIIEYLEETRPTPRLLPQDPKKRASVRMISD
LIAGGIQPLQNLSVLKQVGEEMQLTWAQNAITCGFNALEQILQSTAGIYC
VGDEVTMADLCLVPQVANAERFKVDLTPYPTISSINKRLLVLEAFQVSHP
CRQPDTPT
3D structure
PDB1fw1 Crystal structure of maleylacetoacetate isomerase/glutathione transferase zeta reveals the molecular basis for its remarkable catalytic promiscuity.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.18: glutathione transferase.
5.2.1.2: maleylacetoacetate isomerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SO4 A S15 Q111 Q114 N172 R175 S11 Q107 Q110 N168 R171
BS02 GSH A S14 C16 L38 Q45 Q58 V59 Q71 S72 N115 L116 S117 S10 C12 L34 Q41 Q54 V55 Q67 S68 N111 L112 S113
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004364 glutathione transferase activity
GO:0004602 glutathione peroxidase activity
GO:0005515 protein binding
GO:0016034 maleylacetoacetate isomerase activity
GO:0016740 transferase activity
GO:0016853 isomerase activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006559 L-phenylalanine catabolic process
GO:0006572 tyrosine catabolic process
GO:0006749 glutathione metabolic process
GO:0009072 aromatic amino acid metabolic process
GO:0098869 cellular oxidant detoxification
GO:1990748 cellular detoxification
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:1fw1, PDBe:1fw1, PDBj:1fw1
PDBsum1fw1
PubMed11327815
UniProtO43708|MAAI_HUMAN Maleylacetoacetate isomerase (Gene Name=GSTZ1)

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