Structure of PDB 1fu5 Chain A

Receptor sequence
>1fu5A (length=111) Species: 10116 (Rattus norvegicus) [Search protein sequence]
GMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTL
TLRKGGNNKSIKIFHRDGKYGFSDPLTFNSVVELINHYRNESLAQYNPKL
DVKLLYPVSKY
3D structure
PDB1fu5 NMR structure of the N-SH2 of the p85 subunit of phosphoinositide 3-kinase complexed to a doubly phosphorylated peptide reveals a second phosphotyrosine binding site.
ChainA
ResolutionN/A
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A W13 R20 R38 A40 T42 T49 N58 K59 S60 I61 K62 I63 F72 S73 D74 F78 L84 Y88 N90 E91 S92 L93 Q95 K99 L100 D101 V102 K103 W13 R20 R38 A40 T42 T49 N58 K59 S60 I61 K62 I63 F72 S73 D74 F78 L84 Y88 N90 E91 S92 L93 Q95 K99 L100 D101 V102 K103
External links
PDB RCSB:1fu5, PDBe:1fu5, PDBj:1fu5
PDBsum1fu5
PubMed11123912
UniProtQ63787|P85A_RAT Phosphatidylinositol 3-kinase regulatory subunit alpha (Gene Name=Pik3r1)

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