Structure of PDB 1ftm Chain A

Receptor sequence
>1ftmA (length=258) Species: 10116 (Rattus norvegicus) [Search protein sequence]
KTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKL
TIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFS
KPFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIA
VFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQR
KPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLNEQGLLDKLKNK
WWYDKGEC
3D structure
PDB1ftm Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core.
ChainA
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A E42 H46 E39 H43
BS02 AMQ A Y61 T91 R96 G141 S142 T143 L192 E193 M196 Y220 Y58 T88 R93 G138 S139 T140 L189 E190 M193 Y217 MOAD: Kd=24.8nM
PDBbind-CN: -logKd/Ki=7.61,Kd=24.8nM
BindingDB: Ki=17nM
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:1ftm, PDBe:1ftm, PDBj:1ftm
PDBsum1ftm
PubMed11086992
UniProtP19491|GRIA2_RAT Glutamate receptor 2 (Gene Name=Gria2)

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