Structure of PDB 1ft4 Chain A

Receptor sequence
>1ft4A (length=140) Species: 9606 (Homo sapiens) [Search protein sequence]
MDSVCPQGKYIHPQNNSICCTKCHKGTYLYNDCPGPGQDTDCRECESGSF
TASENHLRHCLSCSKCRKEMGQVEISSCTVDRDTVCGCRKNQYRHYWSEN
LFQCFNCSLCLNGTVHLSCQEKQNTVCTCHAGFFLRENEC
3D structure
PDB1ft4 Photochemically enhanced binding of small molecules to the tumor necrosis factor receptor-1 inhibits the binding of TNF-alpha.
ChainA
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 703 A T61 A62 L67 L71 T51 A52 L57 L61 PDBbind-CN: -logKd/Ki=6.57,IC50=0.27uM
Gene Ontology
Molecular Function
GO:0005031 tumor necrosis factor receptor activity
Biological Process
GO:0006693 prostaglandin metabolic process
GO:0006954 inflammatory response
GO:0033209 tumor necrosis factor-mediated signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:1ft4, PDBe:1ft4, PDBj:1ft4
PDBsum1ft4
PubMed11592999
UniProtP19438|TNR1A_HUMAN Tumor necrosis factor receptor superfamily member 1A (Gene Name=TNFRSF1A)

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