Structure of PDB 1frv Chain A

Receptor sequence
>1frvA (length=262) Species: 879 (Megalodesulfovibrio gigas) [Search protein sequence]
AKKRPSVVYLHNAECTGCSESLLRTVDPYVDELILDVISMDYHETLMAGA
GHAVEEALHEAIKGDFVCVIEGGIPMGDGGYWGKVGRRNMYDICAEVAPK
AKAVIAIGTCATYGGVQAAKPNPTGTVGVNEALGKLGVKAINIAGCPPNP
MNFVGTVVHLLTKGMPELDKQGRPVMFFGETVHDNCPRLKHFEAGEFATS
FGSPEAKKGYCLYELGCKGPDTYNNCPKQLFNQVNWPVQAGHPCIACSEP
NFWDLYSPFYSA
3D structure
PDB1frv Crystal structure of the nickel-iron hydrogenase from Desulfovibrio gigas.
ChainA
Resolution2.85 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C17 C20 C112 C148 H185 C188 C213 C219 C228 P239 C246 C249
Catalytic site (residue number reindexed from 1) C15 C18 C110 C146 H183 C186 C211 C217 C226 P237 C244 C247
Enzyme Commision number 1.12.2.1: cytochrome-c3 hydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SF4 A H185 C188 R190 L191 C213 L214 Y215 C219 P222 H183 C186 R188 L189 C211 L212 Y213 C217 P220
BS02 F3S A N226 C228 F233 W238 P239 C246 I247 C249 N224 C226 F231 W236 P237 C244 I245 C247
BS03 SF4 A E16 C17 G19 C20 G110 C112 C148 P149 E14 C15 G17 C18 G108 C110 C146 P147
Gene Ontology
Molecular Function
GO:0008901 ferredoxin hydrogenase activity
GO:0009055 electron transfer activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
GO:0047806 cytochrome-c3 hydrogenase activity
GO:0051536 iron-sulfur cluster binding
GO:0051538 3 iron, 4 sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0009061 anaerobic respiration
Cellular Component
GO:0009375 ferredoxin hydrogenase complex
GO:0016020 membrane
GO:0042597 periplasmic space
GO:0044569 [Ni-Fe] hydrogenase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1frv, PDBe:1frv, PDBj:1frv
PDBsum1frv
PubMed7854413
UniProtP12943|PHNS_MEGGA Periplasmic [NiFe] hydrogenase small subunit (Gene Name=hydA)

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