Structure of PDB 1fqj Chain A

Receptor sequence
>1fqjA (length=317) Species: 9913,10116 [Search protein sequence]
RTVKLLLLGAGESGKSTIVKQMKIIHQDGYSLEECLEFIAIIYGNTLQSI
LAIVRAMTTLNIQYGDSARQDDARKLMHMADTIEEGTMPKEMSDIIQRLW
KDSGIQACFDRASEYQLNDSAGYYLSDLERLVTPGYVPTEQDVLRSRVKT
TGIIETQFSFKDLNFRMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYD
LVLAEDEEMNRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKIKKS
PLTICYPEYAGSNTYEEAGNYIKVQFLELNMRRDVKEIYSHMTCATDTQN
VKFVFDAVTDIIIKENL
3D structure
PDB1fqj Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 A.
ChainA
Resolution2.02 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E39 T44 R174 D196 Q200
Catalytic site (residue number reindexed from 1) E12 T17 R147 D169 Q173
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A S43 T177 S16 T150
BS02 ALF A G38 E39 K42 R174 K176 T177 G199 G11 E12 K15 R147 K149 T150 G172
BS03 GDP A E39 S40 G41 K42 S43 T44 D146 L171 R172 S173 R174 N265 K266 D268 L269 C321 A322 T323 E12 S13 G14 K15 S16 T17 D119 L144 R145 S146 R147 N238 K239 D241 L242 C294 A295 T296
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0019001 guanyl nucleotide binding
GO:0031683 G-protein beta/gamma-subunit complex binding
Biological Process
GO:0007165 signal transduction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:1fqj, PDBe:1fqj, PDBj:1fqj
PDBsum1fqj
PubMed11234020
UniProtP04695|GNAT1_BOVIN Guanine nucleotide-binding protein G(t) subunit alpha-1 (Gene Name=GNAT1);
P10824|GNAI1_RAT Guanine nucleotide-binding protein G(i) subunit alpha-1 (Gene Name=Gnai1)

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