Structure of PDB 1fq7 Chain A

Receptor sequence
>1fq7A (length=329) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
GGHDVPLTNYLNAQYYTDITLGTPPQNFKVILDTGSSNLWVPSNECGSLA
CFLHSKYDHEASSSYKANGTEFAIQYGTGSLEGYISQDTLSIGDLTIPKQ
DFAEATSEPGLTFAFGKFDGILGLGYDTISVDKVVPPFYNAIQQDLLDEK
RFAFYLGDTSKDTENGGEATFGGIDESKFKGDITWLPVRRKAYWEVKFEG
IGLGDEYAELESHGAAIDTGTSLITLPSGLAEMINAEIGAKKGWTGQYTL
DCNTRDNLPDLIFNFNGYNFTIGPYDYTLEVSGSCISAITPMDFPEPVGP
LAIVGDAFLRKYYSIYDIGNNAVGLAKAI
3D structure
PDB1fq7 X-ray structures of five renin inhibitors bound to saccharopepsin: exploration of active-site specificity.
ChainA
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D32 S35 N37 W39 Y75 D215 T218
Catalytic site (residue number reindexed from 1) D33 S36 N38 W40 Y76 D218 T221
Enzyme Commision number 3.4.23.25: saccharopepsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BMA A Y138 Q142 Y139 Q143
BS02 2Y3 A Q13 I30 D32 G34 Y75 G76 T77 T111 F117 Y189 D215 G217 T218 S219 Q14 I31 D33 G35 Y76 G77 T78 T112 F118 Y193 D218 G220 T221 S222 PDBbind-CN: -logKd/Ki=5.43,Ki=3.74uM
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0000324 fungal-type vacuole

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Molecular Function
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Cellular Component
External links
PDB RCSB:1fq7, PDBe:1fq7, PDBj:1fq7
PDBsum1fq7
PubMed11061973
UniProtP07267|CARP_YEAST Saccharopepsin (Gene Name=PEP4)

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