Structure of PDB 1fpr Chain A

Receptor sequence
>1fprA (length=284) Species: 9606 (Homo sapiens) [Search protein sequence]
GFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGR
DSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQE
NSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKL
RTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQES
LPHAGPIIVHSSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVR
AQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVL
3D structure
PDB1fpr Structural basis for substrate specificity of protein-tyrosine phosphatase SHP-1.
ChainA
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D421 S455 R461 T462 Q502
Catalytic site (residue number reindexed from 1) D177 S211 R217 T218 Q258
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K259 Y278 N280 I281 R360 K362 S455 S456 A457 I459 R461 R494 S498 G499 Q502 K15 Y34 N36 I37 R116 K118 S211 S212 A213 I215 R217 R250 S254 G255 Q258
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:1fpr, PDBe:1fpr, PDBj:1fpr
PDBsum1fpr
PubMed10660565
UniProtP29350|PTN6_HUMAN Tyrosine-protein phosphatase non-receptor type 6 (Gene Name=PTPN6)

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