Structure of PDB 1flj Chain A

Receptor sequence
>1fljA (length=259) Species: 10116 (Rattus norvegicus) [Search protein sequence]
AKEWGYASHNGPEHWHELYPIAKGDNQSPIELHTKDIRHDPSLQPWSVSY
DPGSAKTILNNGKTCRVVFDDTFDRSMLRGGPLSGPYRLRQFHLHWGSSD
DHGSEHTVDGVKYAAELHLVHWNPKYNTFGEALKQPDGIAVVGIFLKIGR
EKGEFQILLDALDKIKTKGKEAPFNHFDPSCLFPACRDYWTYHGSFTTPP
CEECIVWLLLKEPMTVSSDQMAKLRSLFASAENEPPVPLVGNWRPPQPIK
GRVVRASFK
3D structure
PDB1flj Crystal structure of S-glutathiolated carbonic anhydrase III.
ChainA
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K64 H94 H96 E106 H119 T199
Catalytic site (residue number reindexed from 1) K63 H93 H95 E105 H118 T197
Enzyme Commision number 4.2.1.1: carbonic anhydrase.
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 ZN A H94 H96 H119 H93 H95 H118
BS02 GSH A S182 C183 R189 S180 C181 R187
BS03 GSH A A187 C188 E214 A185 C186 E212
Gene Ontology
Molecular Function
GO:0004089 carbonate dehydratase activity
GO:0008270 zinc ion binding
GO:0016151 nickel cation binding
GO:0016791 phosphatase activity
GO:0016829 lyase activity
GO:0046872 metal ion binding
Biological Process
GO:0006730 one-carbon metabolic process
GO:0006979 response to oxidative stress
GO:0009617 response to bacterium
GO:0045471 response to ethanol
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:1flj, PDBe:1flj, PDBj:1flj
PDBsum1flj
PubMed11024467
UniProtP14141|CAH3_RAT Carbonic anhydrase 3 (Gene Name=Ca3)

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