Structure of PDB 1fk8 Chain A

Receptor sequence
>1fk8A (length=240) Species: 285 (Comamonas testosteroni) [Search protein sequence]
MSIIVISGCATGIGAATRKVLEAAGHQIVGIDIRDAEVIADLSTAEGRKQ
AIADVLAKCSKGMDGLVLCAGLGPQTKVLGNVVSVNYFGATELMDAFLPA
LKKGHQPAAVVISSVASAHLAFDKNPLALALEAGEEAKARAIVEHAGEQG
GNLAYAGSKNALTVAVRKRAAAWGEAGVRLNTIAPGATETPFVPPMGRRA
EPSEMASVIAFLMSPAASYVHGAQIVIDGGIDAVMRPTQF
3D structure
PDB1fk8 The crystal structure of 3alpha -hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosteroni shows a novel oligomerization pattern within the short chain dehydrogenase/reductase family.
ChainA
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.50: 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD A G8 T11 G12 I13 D32 D41 L42 C69 A70 G71 L72 V85 I112 S114 Y155 K159 P185 G8 T11 G12 I13 D32 D41 L42 C69 A70 G71 L72 V85 I112 S114 Y155 K159 P185
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0047042 androsterone dehydrogenase (B-specific) activity
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Cellular Component
External links
PDB RCSB:1fk8, PDBe:1fk8, PDBj:1fk8
PDBsum1fk8
PubMed11007791
UniProtP80702|DIDH_COMTE 3-alpha-hydroxysteroid dehydrogenase/carbonyl reductase (Gene Name=hsdA)

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