Structure of PDB 1fjs Chain A

Receptor sequence
>1fjsA (length=234) Species: 9606 (Homo sapiens) [Search protein sequence]
IVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRF
KVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITF
RMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPY
VDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVT
GIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKT
3D structure
PDB1fjs Preparation, characterization, and the crystal structure of the inhibitor ZK-807834 (CI-1031) complexed with factor Xa.
ChainA
Resolution1.92 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 Q192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H42 D88 Q182 G183 D184 S185 G186
Enzyme Commision number 3.4.21.6: coagulation factor Xa.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A D70 N72 Q75 E77 E80 D56 N58 Q61 E63 E66
BS02 Z34 A E97 T98 F174 D189 A190 C191 Q192 S195 V213 W215 G216 G218 C220 E83 T84 F162 D179 A180 C181 Q182 S185 V203 W205 G206 G208 C209 MOAD: Ki=0.11nM
PDBbind-CN: -logKd/Ki=9.96,Ki=0.11nM
BindingDB: Ki=0.11nM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1fjs, PDBe:1fjs, PDBj:1fjs
PDBsum1fjs
PubMed11027132
UniProtP00742|FA10_HUMAN Coagulation factor X (Gene Name=F10)

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