Structure of PDB 1fiz Chain A

Receptor sequence
>1fizA (length=263) Species: 9823 (Sus scrofa) [Search protein sequence]
VVGGMSAEPGAWPWMVSLQIFMYHNNRRYHTCGGILLNSHWVLTAAHCFK
NKKKVTDWRLIFGANEVVWGSNKPVKPPLQERFVEEIIIHEKYVSGLEIN
DIALIKITPPVPCGPFIGPGCLPQFKAGPPRAPQTCWVTGWGYLKEKGPR
TSPTLQEARVALIDLELCNSTRWYNGRIRSTNVCAGYPRGKIDTCQGDSG
GPLMCRDRAENTFVVVGITSWGVGCARAKRPGVYTSTWPYLNWIASKIGS
NALQMVQLGTPPR
3D structure
PDB1fiz Effector sites in the three-dimensional structure of mammalian sperm beta-acrosin.
ChainA
Resolution2.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 Q192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H47 D101 Q196 G197 D198 S199 G200
Enzyme Commision number 3.4.21.10: acrosin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A P24 G25 A26 W27 W29 S49 C114 G115 P116 F117 I118 G119 P120 G121 C122 T202D M249 V250 P9 G10 A11 W12 W14 S39 C113 G114 P115 F116 I117 G118 P119 G120 C121 T212 M255 V256
BS02 PBZ A D189 T190 C191 Q192 W215 G216 G219 D193 T194 C195 Q196 W221 G222 G224
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1fiz, PDBe:1fiz, PDBj:1fiz
PDBsum1fiz
PubMed11080640
UniProtP08001|ACRO_PIG Acrosin (Gene Name=ACR)

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