Structure of PDB 1fh0 Chain A

Receptor sequence
>1fh0A (length=221) Species: 9606 (Homo sapiens) [Search protein sequence]
LPKSVDWRKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSE
QNLVDCSRPQGNQGCNGGFMARAFQYVKENGGLDSEESYPYVAVDEICKY
RPENSVAQDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKSG
IYFEPDCSSKNLDHGVLVVGYGFEGANSDNSKYWLVKNSWGPEWGSNGYV
KIAKDKNNHCGIATAASYPNV
3D structure
PDB1fh0 Crystal structure of human cathepsin V.
ChainA
Resolution1.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q19 C25 H163 N187
Catalytic site (residue number reindexed from 1) Q19 C25 H164 N188
Enzyme Commision number 3.4.22.43: cathepsin V.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0IW A Q19 G23 C25 Q63 N66 G67 G68 F69 A135 D162 H163 W189 Q19 G23 C25 Q63 N66 G67 G68 F69 A136 D163 H164 W190
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1fh0, PDBe:1fh0, PDBj:1fh0
PDBsum1fh0
PubMed11027133
UniProtO60911|CATL2_HUMAN Cathepsin L2 (Gene Name=CTSV)

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