Structure of PDB 1fgs Chain A

Receptor sequence

>1fgsA (length=393) Species: 1582 (Lacticaseibacillus casei)

MNYTETVAYIHSFPRLAGDHRRILTLLHALGNPQQQGRYIHVTGTNGKGS
AANAIAHVLEASGLTVGLYTSPFIMRFNERIMIDHEPIPDAALVNAVAFV
RAALERLQQQQADFNVTEFEFITALAYWYFRQRQVDVAVIEVGDSTNVIT
PVVSVLTEVALDTITAIAKHKAGIIKRGIPVVTGNLVPDAAAVVAAKVAT
TGSQWLRFDRDFSVPKAKLHGWGQRFTYEDQDGRISDLEVPLVGDYQQRN
MAIAIQTAKVYAKQTEWPLTPQNIRQGLAASHWPARLEKISDTPLIVIDG
AHNPDGINGLITALKQLFSQPITVIAGYAAMADRLTAAFSTVYLVPVPGT
PRGRLKDSWQEALAASLNDVPDQPIVITGSLYLASAVRQTLLG

3D structure

• PDB: 1fgs Structural homologies with ATP- and folate-binding enzymes in the crystal structure of folylpolyglutamate synthetase.
• Chain: A
• Resolution: 2.4 Å

Enzymatic activity

• Enzyme Commision number: 6.3.2.17: tetrahydrofolate synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MG	A	S73 E143	S71 E141
BS02	POP	A	G49 G51 S52	G47 G49 S50

Gene Ontology

Molecular Function

• GO:0004326 tetrahydrofolylpolyglutamate synthase activity
• GO:0005524 ATP binding
• GO:0008841 dihydrofolate synthase activity
• GO:0016874 ligase activity
• GO:0016881 acid-amino acid ligase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006730 one-carbon metabolic process
• GO:0006761 dihydrofolate biosynthetic process
• GO:0009058 biosynthetic process
• GO:0009396 folic acid-containing compound biosynthetic process
• GO:0046901 tetrahydrofolylpolyglutamate biosynthetic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:1fgs, PDBe:1fgs, PDBj:1fgs
• PDBsum: 1fgs
• PubMed: 9618466
• UniProt: P15925|FPGS_LACCA Folylpolyglutamate synthase (Gene Name=fpgS)