Structure of PDB 1fgh Chain A

Receptor sequence
>1fghA (length=753) Species: 9913 (Bos taurus) [Search protein sequence]
RAKVAMSHFEPHEYIRYDLLEKNIDIVRKRLNRPLTLSEKIVYGHLDDPA
NQEIERGKTYLRLRPDRVAMQDATAQMAMLQFISSGLPKVAVPSTIHCDH
LIEAQLGGEKDLRRAKDINQEVYNFLATAGAKYGVGFWRPGSGIIHQIIL
ENYAYPGVLLIGTDSHTPNGGGLGGICIGVGGADAVDVMAGIPWELKCPK
VIGVKLTGSLSGWTSPKDVILKVAGILTVKGGTGAIVEYHGPGVDSISCT
GMATICNMGAEIGATTSVFPYNHRMKKYLSKTGRADIANLADEFKDHLVP
DSGCHYDQLIEINLSELKPHINGPFTPDLAHPVAEVGSVAEKEGWPLDIR
VGLIGSCTNSSYEDMGRSAAVAKQALAHGLKCKSQFTITPGSEQIRATIE
RDGYAQVLRDVGGIVLANACGPCIGQWDRKDIKKGEKNTIVTSYNRNFTG
RNDANPETHAFVTSPEIVTALAIAGTLKFNPETDFLTGKDGKKFKLEAPD
ADELPRAEFDPGQDTYQHPPKDSSGQRVDVSPTSQRLQLLEPFDKWDGKD
LEDLQILIKVKGKCTTDHISAAGPWLKFRGHLDNISNNLLIGAINSENRK
ANSVRNAVTQEFGPVPDTARYYKQHGIRWVVIGDENYGEGSSREHSALEP
RFLGGRAIITKSFARIHETNLKKQGLLPLTFADPADYNKIHPVDKLTIQG
LKDFAPGKPLTCIIKHPNGTQETILLNHTFNETQIEWFRAGSALNRMKEL
QQK
3D structure
PDB1fgh The reaction of fluorocitrate with aconitase and the crystal structure of the enzyme-inhibitor complex.
ChainA
Resolution2.05 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D100 H101 D165 R447 S642 R644
Catalytic site (residue number reindexed from 1) D99 H100 D164 R446 S641 R643
Enzyme Commision number 4.2.1.3: aconitate hydratase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SF4 A H101 D165 H167 S357 C358 C421 C424 I425 R452 H100 D164 H166 S356 C357 C420 C423 I424 R451
BS02 ATH A Q72 T75 H101 D165 S166 R447 R452 R580 S642 S643 R644 Q71 T74 H100 D164 S165 R446 R451 R579 S641 S642 R643
Gene Ontology
Molecular Function
GO:0003994 aconitate hydratase activity
GO:0005506 iron ion binding
GO:0008198 ferrous iron binding
GO:0016829 lyase activity
GO:0046872 metal ion binding
GO:0051538 3 iron, 4 sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0006099 tricarboxylic acid cycle
GO:0006101 citrate metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1fgh, PDBe:1fgh, PDBj:1fgh
PDBsum1fgh
PubMed8942997
UniProtP20004|ACON_BOVIN Aconitate hydratase, mitochondrial (Gene Name=ACO2)

[Back to BioLiP]