Structure of PDB 1fgg Chain A

Receptor sequence
>1fggA (length=250) Species: 9606 (Homo sapiens) [Search protein sequence]
MTIYVVTPTYARLVQKAELVRLSQTLSLVPRLHWLLVEDAEGPTPLVSGL
LAASGLLFTHLVVLTPWVHPRGVEQRNKALDWLRGRGGAVGGEKDPPPPG
TQGVVYFADDDNTYSRELFEEMRWTRGVSVWPVGLVGGLRFEGPQVQDGR
VVGFHTAWEPSRPFPVDMAGFAVALPLLLDKPNAQFDSTAPRGHLESSLL
SHLVDPKDLEPRAANCTRVLVWHTRTEKPKMKQEEQLQRQGRGSDPAIEV
3D structure
PDB1fgg Heparan/chondroitin sulfate biosynthesis. Structure and mechanism of human glucuronyltransferase I.
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D196 E281
Catalytic site (residue number reindexed from 1) D111 E196
Enzyme Commision number 2.4.1.135: galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GAL A G222 W243 G137 W158
BS02 GAL A E227 W243 R247 D252 E281 E142 W158 R162 D167 E196
BS03 MN A D196 R310 D111 R225
BS04 UDP A P82 Y84 D113 R156 D194 D195 D196 H308 R310 P8 Y10 D39 R71 D109 D110 D111 H223 R225
Gene Ontology
Molecular Function
GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:1fgg, PDBe:1fgg, PDBj:1fgg
PDBsum1fgg
PubMed10946001
UniProtO94766|B3GA3_HUMAN Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 (Gene Name=B3GAT3)

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