Structure of PDB 1fcx Chain A

Receptor sequence
>1fcxA (length=235) Species: 9606 (Homo sapiens) [Search protein sequence]
SPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSE
LATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPE
QDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLS
AICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMK
ITDLRGISTKGAERAITLKMEIPGPMPPLIREMLE
3D structure
PDB1fcx Structural basis for isotype selectivity of the human retinoic acid nuclear receptor.
ChainA
Resolution1.47 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 184 A F230 A234 C237 L271 M272 I275 F288 S289 G303 F304 F48 A52 C55 L89 M90 I93 F106 S107 G121 F122 MOAD: Kd=64nM
PDBbind-CN: -logKd/Ki=7.19,Kd=64nM
BindingDB: Kd=64nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0048384 retinoic acid receptor signaling pathway
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Cellular Component
External links
PDB RCSB:1fcx, PDBe:1fcx, PDBj:1fcx
PDBsum1fcx
PubMed10964567
UniProtP13631|RARG_HUMAN Retinoic acid receptor gamma (Gene Name=RARG)

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