Structure of PDB 1f9b Chain A

Receptor sequence

>1f9bA (length=689) Species: 9796 (Equus caballus)

APRKSVRWCTISPAEAAKCAKFQRNMKKVRGPSVSCIRKTSSFECIQAIA
ANKADAVTLDGGLVYEAGLHPYKLRPVAAEVYQTRGKPQTRYYAVAVVKK
GSGFQLNQLQGVKSCHTGLGRSAGWNIPIGTLRPYLNWTGPPEPLQKAVA
NFFSASCVPCADGKQYPNLCRLCAGTEADKCACSSQEPYFGYSGAFKCLE
NGAGDVAFVKDSTVFENLPDEAERDKYELLCPDNTRKPVDAFKECHLARV
PSHAVVARSVDGREDLIWKLLHRAQEEFGRNKSSAFQLFKSTPEEQDLLF
KDSALGFVRIPSQIDSGLYLGANYLTATQNLRETAAEVAARRERVVWCAV
GPEEERKCKQWSDVSNRKVACASASTTEECIALVLKGEADALNLDGGFIY
VAGKCGLVPVLAENQKSQNSNAPDCVHRPPEGYLAVAVVRKSDADLTWNS
LSGKKSCHTGVGRTAAWNIPMGLLFNQTGSCKFDKFFSQSCAPGADPQSS
LCALCVGNNENENKCMPNSEERYYGYTGAFRCLAEKAGDVAFVKDVTVLQ
NTDGKNSEPWAKDLKQEDFELLCLDGTRKPVAEAESCHLARAPNHAVVSQ
SDRAQHLKKVLFLQQDQFGGNGPDCPGKFCLFKSETKNLLFNDNTECLAE
LQGKTTYEQYLGSEYVTSITNLRRCSSSPLLEACAFLRA

3D structure

• PDB: 1f9b Lactoferrin-melanin interaction and its possible implications in melanin polymerization: crystal structure of the complex formed between mare lactoferrin and melanin monomers at 2.7-A resolution.
• Chain: A
• Resolution: 2.7 Å

Enzymatic activity

• Enzyme Commision number: 3.4.21.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FE	A	D60 Y92 Y192 H253	D60 Y92 Y192 H253
BS02	FE	A	D395 Y433 Y526 H595	D395 Y433 Y526 H595
BS03	BCT	A	D60 T117 R121 A123 Y192	D60 T117 R121 A123 Y192
BS04	BCT	A	D395 T459 R463 A465 Y526	D395 T459 R463 A465 Y526
BS05	3ID	A	W8 C9 T10 I11 E15 V57 T58 L299 F300	W8 C9 T10 I11 E15 V57 T58 L299 F300
BS06	3ID	A	E354 R463 S519 Y524 N638	E354 R463 S519 Y524 N638

Gene Ontology

Cellular Component

• GO:0005576 extracellular region
• GO:0005615 extracellular space

External links

• PDB: RCSB:1f9b, PDBe:1f9b, PDBj:1f9b
• PDBsum: 1f9b
• PubMed: 11599026
• UniProt: O77811|TRFL_HORSE Lactotransferrin (Fragment) (Gene Name=LTF)