Structure of PDB 1f86 Chain A

Receptor sequence
>1f86A (length=115) Species: 9606 (Homo sapiens) [Search protein sequence]
CPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLT
TEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAA
LLSPYSYSTMAVVTN
3D structure
PDB1f86 Transthyretin stability as a key factor in amyloidogenesis: X-ray analysis at atomic resolution.
ChainA
Resolution1.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 T44 A L17 A108 A109 L110 L8 A99 A100 L101 BindingDB: IC50=10500nM
Gene Ontology
Molecular Function
GO:0005179 hormone activity
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0070324 thyroid hormone binding
Biological Process
GO:0006144 purine nucleobase metabolic process
GO:0007165 signal transduction
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0035578 azurophil granule lumen
GO:0070062 extracellular exosome

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Molecular Function
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Cellular Component
External links
PDB RCSB:1f86, PDBe:1f86, PDBj:1f86
PDBsum1f86
PubMed11243784
UniProtP02766|TTHY_HUMAN Transthyretin (Gene Name=TTR)

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