Structure of PDB 1f6o Chain A

Receptor sequence
>1f6oA (length=211) Species: 9606 (Homo sapiens) [Search protein sequence]
KGHLTRLGLEFFDQPAVPLARAFLGQVLVRRLPNGTELRGRIVETEAYLG
PEDEAAHSRGGRQTPRNRGMFMKPGTLYVYIIYGMYFCMNISSQGDGACV
LLRALEPLEGLETMRQLRSTLSRVLKDRELCSGPSKLCQALAINKSFDQR
DLAQDEAVWLERGPLEPSEPAVVAAARVGVGHAGEWARKPLRFYVRGSPW
VSVVDRVAEQD
3D structure
PDB1f6o Molecular basis for discriminating between normal and damaged bases by the human alkyladenine glycosylase, AAG.
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.2.21: DNA-3-methyladenine glycosylase II.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A Y127 H136 Y159 I161 Y162 Y165 R197 G217 P218 S219 K220 G263 H266 Y48 H57 Y80 I82 Y83 Y86 R118 G133 P134 S135 K136 G179 H182
BS02 dna A R141 T143 P144 R145 Y162 G163 M164 R62 T64 P65 R66 Y83 G84 M85
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0003905 alkylbase DNA N-glycosylase activity
Biological Process
GO:0006284 base-excision repair

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Molecular Function
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Biological Process
External links
PDB RCSB:1f6o, PDBe:1f6o, PDBj:1f6o
PDBsum1f6o
PubMed11106395
UniProtP29372|3MG_HUMAN DNA-3-methyladenine glycosylase (Gene Name=MPG)

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