Structure of PDB 1f59 Chain A

Receptor sequence
>1f59A (length=440) Species: 9606 (Homo sapiens) [Search protein sequence]
MELITILEKTVSPDRLELEAAQKFLERAAVENLPTFLVELSRVLANPGNS
QVARVAAGLQIKNSLTSKDPDIKAQYQQRWLAIDANARREVKNYVLHTLG
TETYRPSSASQCVAGIACAEIPVNQWPELIPQLVANVTNPNSTEHMKEST
LEAIGYICQDIDPEQLQDKSNEILTAIIQGMRKEEPSNNVKLAATNALLN
SLEFTKANFDKESERHFIMQVVCEATQCPDTRVRVAALQNLVKIMSLYYQ
YMETYMGPALFAITIEAMKSDIDEVALQGIEFWSNVCDEEMDLAIEASEA
AEQGRPPEHTSKFYAKGALQYLVPILTQTLTKQDENDDDDDWNPCKAAGV
CLMLLATCCEDDIVPHVLPFIKEHIKNPDWRYRDAAVMAFGCILEGPEPS
QLKPLVIQAMPTLIELMKDPSVVVRDTAAWTVGRICELLP
3D structure
PDB1f59 Structural basis for the interaction between FxFG nucleoporin repeats and importin-beta in nuclear trafficking.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A N171 L174 T175 I178 Q179 R182 K211 S213 E214 H216 F217 I218 M219 Q220 C223 E224 Y255 A259 I263 N171 L174 T175 I178 Q179 R182 K211 S213 E214 H216 F217 I218 M219 Q220 C223 E224 Y255 A259 I263
Gene Ontology
Molecular Function
GO:0031267 small GTPase binding
Biological Process
GO:0006606 protein import into nucleus
GO:0006886 intracellular protein transport

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Molecular Function
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Biological Process
External links
PDB RCSB:1f59, PDBe:1f59, PDBj:1f59
PDBsum1f59
PubMed10929717
UniProtQ14974|IMB1_HUMAN Importin subunit beta-1 (Gene Name=KPNB1)

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