Structure of PDB 1f3t Chain A

Receptor sequence
>1f3tA (length=378) Species: 5691 (Trypanosoma brucei) [Search protein sequence]
RFLEGFNTRDALCKKISGDPFFVADLGDIVRKHETWKKCLPRVTPFYAVK
CNDDWRVLGTLAALGTGFDCASNTEIQRVRGIGVPPEKIIYANPCKQISH
IRYARDSGVDVMTFDCVDELEKVAKTHPKAKMVLRISTVKFGAKVEDCRF
ILEQAKKLNIDVTGVSFHVGSGSTDASTFAQAISDSRFVFDMGTELGFNM
HILDIGGGFPGTRDAPLKFEEIAGVINNALEKHFPPDLKLTIVAEPGRYY
VASAFTLAVNVIAKKVTQSFMYYVNDGVYGSFNCILYDHAVVRPLPQREP
IPNEKLYPSSVWGPTCDGLDQIVERYYLPEMQVGEWLLFEDMGAYTVVGT
SSFNGFQSPTIYYVVSGLPDHVVRELKS
3D structure
PDB1f3t Altering the reaction specificity of eukaryotic ornithine decarboxylase.
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K69 H197 E274
Catalytic site (residue number reindexed from 1) K50 H168 E245
Enzyme Commision number 4.1.1.17: ornithine decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP A K69 H197 G237 E274 G276 R277 Y389 K50 H168 G208 E245 G247 R248 Y345
BS02 PUT A Y331 D332 Y389 Y287 D288 Y345
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004586 ornithine decarboxylase activity
GO:0016831 carboxy-lyase activity
Biological Process
GO:0006596 polyamine biosynthetic process
GO:0033387 putrescine biosynthetic process from ornithine
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1f3t, PDBe:1f3t, PDBj:1f3t
PDBsum1f3t
PubMed10985770
UniProtP07805|DCOR_TRYBB Ornithine decarboxylase

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