Structure of PDB 1f2p Chain A

Receptor sequence
>1f2pA (length=274) Species: 1911 (Streptomyces griseus) [Search protein sequence]
APDIPLANVKAHLTQLSTIAANNGGNRAHGRPGYKASVDYVKAKLDAAGY
TTTLQQFTSGGATGYNLIANWPGGDPNKVLMAGAHLDSVSSGAGINDNGS
GSAAVLETALAVSRAGYQPDKHLRFAWWGAEELGLIGSKFYVNNLPSADR
SKLAGYLNFDMIGSPNPGYFVYDDDPVIEKTFKNYFAGLNVPTEIETERS
DHAPFKNVGVPVGGLFTGAGYTKSAAQAQKWGGTAGQAFDRCYHSSCDSL
SNINDTALDRNSDAAAHAIWTLSS
3D structure
PDB1f2p Interactions of Streptomyces griseus aminopeptidase with amino acid reaction products and their implications toward a catalytic mechanism.
ChainA
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N77 D97 E131 E132 D160
Catalytic site (residue number reindexed from 1) N77 D97 E131 E132 D160
Enzyme Commision number 3.4.11.24: aminopeptidase S.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H85 D97 D160 H85 D97 D160
BS02 ZN A D97 E132 H247 D97 E132 H244
BS03 CA A D3 I4 D262 D266 D3 I4 D259 D263
BS04 PHE A E131 E132 D160 R202 F219 Y246 E131 E132 D160 R199 F216 Y243 MOAD: Ki=12.7mM
PDBbind-CN: -logKd/Ki=1.90,Ki=12.7mM
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0008235 metalloexopeptidase activity
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1f2p, PDBe:1f2p, PDBj:1f2p
PDBsum1f2p
PubMed11484227
UniProtP80561|APX_STRGG Aminopeptidase S (Gene Name=SGR_5809)

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