Structure of PDB 1f0x Chain A

Receptor sequence
>1f0xA (length=502) Species: 562 (Escherichia coli) [Search protein sequence]
NKAFLNELARLVGSSHLLTDPAKTARYRKGFRSGQGDALAVVFPGSLLEL
WRVLKACVTADKIILMQAANTGLTEGSTPNGNDYDRDVVIISTLRLDKLH
VLGKGEQVLAYPGTTLYSLEKALKPLGREPHSVIGSSCIGASVIGGICNN
SGGSLVQRGPAYTEMSLFARINEDGKLTLVNHLGIDLGETPEQILSKLDD
DRIKDDDVRHDGRHAHDYDYVHRVRDIEADTPARYNADPDRLFESSGCAG
KLAVFAVRLDTFEAEKNQQVFYIGTNQPEVLTEIRRHILANFENLPVAGE
YMHRDIYDIAELPPRMKNWRDKYEHHLLLKMAGDGVGEAKSWLVDYFKQA
EGDFFVCTPEEGSKAFLHRFAAAGAAIRYQAVHSDEVEDILALDIALRRN
DTEWYEHLPPEIDSQLVHKLYYGHFMCYVFHQDYIVKKGVDVHALKEQML
ELLQQRGAQYPAEHNVGHLYKAPETLQKFYRENDPTNSMNPGIGKTSKRK
NW
3D structure
PDB1f0x The crystal structure of D-lactate dehydrogenase, a peripheral membrane respiratory enzyme.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.5.12: D-lactate dehydrogenase (quinone).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A F39 M74 A76 A77 N78 T79 G80 L81 G84 S85 I142 G143 S144 S150 I152 C156 S159 G160 A257 G258 V262 E528 H529 F31 M66 A68 A69 N70 T71 G72 L73 G76 S77 I134 G135 S136 S142 I144 C148 S151 G152 A249 G250 V254 E463 H464
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0009055 electron transfer activity
GO:0016491 oxidoreductase activity
GO:0016901 oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor
GO:0048038 quinone binding
GO:0050660 flavin adenine dinucleotide binding
GO:0071949 FAD binding
GO:0102029 D-lactate dehydrogenase (quinone) activity
Biological Process
GO:0006089 lactate metabolic process
GO:0009060 aerobic respiration
GO:0009061 anaerobic respiration
GO:0022904 respiratory electron transport chain
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0009898 cytoplasmic side of plasma membrane
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane

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Cellular Component
External links
PDB RCSB:1f0x, PDBe:1f0x, PDBj:1f0x
PDBsum1f0x
PubMed10944213
UniProtP06149|DLD_ECOLI Quinone-dependent D-lactate dehydrogenase (Gene Name=dld)

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