Structure of PDB 1f0p Chain A

Receptor sequence
>1f0pA (length=284) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
SRPGLPVEYLQVPSPSMGRDIKVQFQSGGNNSPAVYLLDGLRAQDDYNGW
DINTPAFEWYYQSGLSIVMPVGGQSSFYSDWYSPACGKAGCQTYKWETFL
TSELPQWLSANRAVKPTGSAAIGLSMAGSSAMILAAYHPQQFIYAGSLSA
LLDPSQGMGPSLIGLAMGDAGGYKAADMWGPSSDPAWERNDPTQQIPKLV
ANNTRLWVYCGNGTPNELGGANIPAEFLENFVRSSNLKFQDAYNAAGGHN
AVFNFPPNGTHSWEYWGAQLNAMKGDLQSSLGAG
3D structure
PDB1f0p An interfacial mechanism and a class of inhibitors inferred from two crystal structures of the Mycobacterium tuberculosis 30 kDa major secretory protein (Antigen 85B), a mycolyl transferase.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.122: trehalose O-mycolyltransferase.
2.3.1.20: diacylglycerol O-acyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLC A G41 L42 R43 S126 W264 G40 L41 R42 S125 W263
BS02 GLC A R43 A226 H262 R42 A225 H261
BS03 GLC A L152 D154 L163 F232 K239 L151 D153 L162 F231 K238
BS04 GLC A F232 S235 F231 S234
Gene Ontology
Molecular Function
GO:0001968 fibronectin binding
GO:0004144 diacylglycerol O-acyltransferase activity
GO:0005515 protein binding
GO:0016746 acyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
GO:0035375 zymogen binding
GO:0050348 trehalose O-mycolyltransferase activity
Biological Process
GO:0010756 positive regulation of plasminogen activation
GO:0040009 regulation of growth rate
GO:0046677 response to antibiotic
GO:0052572 response to host immune response
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1f0p, PDBe:1f0p, PDBj:1f0p
PDBsum1f0p
PubMed11254389
UniProtP9WQP1|A85B_MYCTU Diacylglycerol acyltransferase/mycolyltransferase Ag85B (Gene Name=fbpB)

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