Structure of PDB 1f0l Chain A

Receptor sequence
>1f0lA (length=520) Species: 1717 (Corynebacterium diphtheriae) [Search protein sequence]
GADDVVDSSKSFVMENFSSYHGTKPGYVDSIQKGIQKPKSGTQGNYDDDW
KGFYSTDNKYDAAGYSVDNENPLSGKAGGVVKVTYPGLTKVLALKVDNAE
TIKKELGLSLTEPLMEQVGTEEFIKRFGDGASRVVLSLPFAEGSSSVEYI
NNWEQAKALSVELEINFETRGKRGQDAMYEYMAQACACINLDWDVIRDKT
KTKIESLKEHGPIKNKMSESPNKTVSEEKAKQYLEEFHQTALEHPELSEL
KTVTGTNPVFAGANYAAWAVNVAQVIDSETADNLEKTTAALSILPGIGSV
MGIADGAVHHNTEEIVAQSIALSSLMVAQAIPLVGELIGFAAYNFVESII
NLFQVVHNSYNRPAYSPGHKTQPFLHDGYAVSWNTVEDSIIRTGFQGESG
HDIKITAENTPLPIAGVLLPTIPGKLDVNKSKTHISVNGRKIRMRCRAID
GDVTFCRPKSPVYVGNGVHANLHVAFHRSSSEKIHSNEISSDSIGVLGYQ
KTVDHTKVNSKLSLFFEIKS
3D structure
PDB1f0l Characterization of High-Order Oligomerization and Energetics in Diphtheria Toxin
ChainA
Resolution1.55 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E148
Catalytic site (residue number reindexed from 1) E148
Enzyme Commision number 2.4.2.36: NAD(+)--diphthamide ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 APU A H21 G22 K24 Y27 I31 I35 Q36 T42 G44 F53 Y54 Y65 W153 S446 R458 H21 G22 K24 Y27 I31 I35 Q36 T42 G44 F53 Y54 Y65 W153 S431 R443
Gene Ontology
Molecular Function
GO:0008320 protein transmembrane transporter activity
GO:0016757 glycosyltransferase activity
GO:0016779 nucleotidyltransferase activity
GO:0042802 identical protein binding
GO:0047286 NAD+-diphthamide ADP-ribosyltransferase activity
GO:0090729 toxin activity
Biological Process
GO:0035821 modulation of process of another organism
GO:0071806 protein transmembrane transport
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1f0l, PDBe:1f0l, PDBj:1f0l
PDBsum1f0l
PubMed
UniProtP00588|DTX_CORBE Diphtheria toxin

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