Structure of PDB 1ex7 Chain A

Receptor sequence
>1ex7A (length=186) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
SRPIVISGPSGTGKSTLLKKLFAEYPDSFGFSVSSTTRTPRAGEVNGKDY
NFVSVDEFKSMIKNNEFIEWAQFSGNYYGSTVASVKQVSKSGKTCILDID
MQGVKSVKAIPELNARFLFIAPPSVEDLKKRLEGRGTETEESINKRLSAA
QAELAYAETGAHDKVIVNDDLDKAYKELKDFIFAEK
3D structure
PDB1ex7 Crystal structure of unligated guanylate kinase from yeast reveals GMP-induced conformational changes.
ChainA
Resolution1.9 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.4.8: guanylate kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5GP A S34 R38 R41 Y50 E69 F73 Y78 G79 S80 I99 D100 S34 R38 R41 Y50 E69 F73 Y78 G79 S80 I99 D100
Gene Ontology
Molecular Function
GO:0004385 guanylate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
Biological Process
GO:0006163 purine nucleotide metabolic process
GO:0016310 phosphorylation
GO:0046037 GMP metabolic process
GO:0046711 GDP biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1ex7, PDBe:1ex7, PDBj:1ex7
PDBsum1ex7
PubMed11243817
UniProtP15454|KGUA_YEAST Guanylate kinase (Gene Name=GUK1)

[Back to BioLiP]