Structure of PDB 1ewn Chain A

Receptor sequence
>1ewnA (length=200) Species: 9606 (Homo sapiens) [Search protein sequence]
HLTRLGLEFFDQPAVPLARAFLGQVLVRRLPNGTELRGRIVETQAYLGPE
DEAAHSRGGRQTPRNRGMFMKPGTLYVYIIYGMYFCMNISSQGDGACVLL
RALEPLEGLETMRQLRSTVLKDRELCSGPSKLCQALAINKSFDQRDLAQD
EAVWLERGPAVVAAARVGVGHAGEWARKPLRFYVRGSPWVSVVDRVAEQD
3D structure
PDB1ewn Molecular basis for discriminating between normal and damaged bases by the human alkyladenine glycosylase, AAG.
ChainA
Resolution2.1 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.2.2.21: DNA-3-methyladenine glycosylase II.
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 dna A Y127 A135 H136 M149 Y159 I161 Y162 Y165 N169 C178 R182 R197 G217 P218 S219 K220 G263 Y46 A54 H55 M68 Y78 I80 Y81 Y84 N88 C97 R101 R116 G128 P129 S130 K131 G168
BS02 dna A R141 T143 R145 Y162 G163 M164 R60 T62 R64 Y81 G82 M83
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0003905 alkylbase DNA N-glycosylase activity
Biological Process
GO:0006284 base-excision repair

View graph for
Molecular Function

View graph for
Biological Process
External links
PDB RCSB:1ewn, PDBe:1ewn, PDBj:1ewn
PDBsum1ewn
PubMed11106395
UniProtP29372|3MG_HUMAN DNA-3-methyladenine glycosylase (Gene Name=MPG)

[Back to BioLiP]