Structure of PDB 1ewk Chain A

Receptor sequence
>1ewkA (length=448) Species: 10116 (Rattus norvegicus) [Search protein sequence]
RSVARMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFHT
LDKINADPVLLPNITLGSEIRDSCWHSSVALEQSIEFIRKPIAGVIGPGS
SSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARA
MLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYSN
AGEKSFDRLLRKLRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSL
IGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLDTNTR
NPWFPEFWQHRFQCRLPGHLLENPNFKKVCTGNESLEENYVQDSKMGFVI
NAIYAMAHGLQNMHHALCPGHVGLCDAMKPIDGRKLLDFLIKSSFVGVSG
EEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWHEGVLNIDDYKI
3D structure
PDB1ewk Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A I89 D92 L95 L96 I54 D57 L60 L61
BS02 GLU A Y74 S165 S186 A187 T188 Y236 D318 K409 Y39 S101 S122 A123 T124 Y172 D254 K345
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1ewk, PDBe:1ewk, PDBj:1ewk
PDBsum1ewk
PubMed11069170
UniProtP23385|GRM1_RAT Metabotropic glutamate receptor 1 (Gene Name=Grm1)

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