Structure of PDB 1eus Chain A

Receptor sequence
>1eusA (length=358) Species: 1881 (Micromonospora viridifaciens) [Search protein sequence]
GEPLYTEQDLAVNGREGFPNYRIPALTVTPDGDLLASYDGRPTGIDAPGP
NSILQRRSTDGGRTWGEQQVVSAGQTTAPIKGFSDPSYLVDRETGTIFNF
HVYSQRQGFAGSRPGTDPADPNVLHANVATSTDGGLTWSHRTITADITPD
PGWRSRFAASGEGIQLRYGPHAGRLIQQYTIINAAGAFQAVSVYSDDHGR
TWRAGEAVGVGMDENKTVELSDGRVLLNSRDSARSGYRKVAVSTDGGHSY
GPVTIDRDLPDPTNNASIIRAFPDAPAGSARAKVLLFSNAASQTSRSQGT
IRMSCDDGQTWPVSKVFQPGSMSYSTLTALPDGTYGLLYEPGTGIRYANF
NLAWLGGI
3D structure
PDB1eus The three domains of a bacterial sialidase: a beta-propeller, an immunoglobulin module and a galactose-binding jelly-roll.
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D92 E260 Y370
Catalytic site (residue number reindexed from 1) D46 E214 Y324
Enzyme Commision number 3.2.1.18: exo-alpha-sialidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DAN A R68 D92 D131 F203 D259 R276 R342 Y370 R22 D46 D85 F157 D213 R230 R296 Y324
Gene Ontology
Molecular Function
GO:0004308 exo-alpha-sialidase activity

View graph for
Molecular Function
External links
PDB RCSB:1eus, PDBe:1eus, PDBj:1eus
PDBsum1eus
PubMed8591030
UniProtQ02834|NANH_MICVI Sialidase (Gene Name=nedA)

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