Structure of PDB 1eu1 Chain A

Receptor sequence

>1eu1A (length=767) Species: 1063 (Cereibacter sphaeroides)

ANGEVMSGCHWGVFKARVENGRAVAFEPWDKDPAPSHQLPGVLDSIYSPT
RIKYPMVRREFLEKGVNADRSTRGNGDFVRVTWDEALDLVARELKRVQES
YGPTGTFGGSYGWKSPGRLHNCQVLMRRALNLAGGFVNSSGDYSTAAAQI
IMPHVMGTLEVYEQQTAWPVVVENTDLMVFWAADPMKTNEIGWVIPDHGA
YAGMKALKEKGTRVICINPVRTETADYFGADVVSPRPQTDVALMLGMAHT
LYSEDLHDKDFLENCTTGFDLFAAYLTGESDGTPKTAEWAAEICGLPAEQ
IRELARSFVAGRTMLAAGWSIQRMHHGEQAHWMLVTLASMIGQIGLPGGG
FGLSYHYSNGGSPTSDGPALGGISDGGEGGATSIPCARVVDMLLNPGGEF
QFNGATATYPDVKLAYWAGGNPFAHHQDRNRMLKAWEKLETFIVQDFQWT
ATARHADIVLPATTSYERNDIESVGDYSNRAILAMKKVVDPLYEARSDYD
IFAALAERLGKGAEFTEGRDEMGWISSFYEAAVKQAEFKNVAMPSFEDFW
SEGIVEFPITEGANFVRYADFREDPLFNPLGTPSGLIEIYSKNIEKMGYD
DCPAHPTWMEPAERLGGAGAKYPLHVVASHPKSRLHSQLNGTSLRDLYAV
AGHEPCLINPADAAARGIADGDVLRVFNDRGQILVGAKVSDAVMPGAIQI
YEGGWYDPLDPSEEGTLDKYGDVNVLSLDVGTSKLAQGNCGQTILADVEK
YAGAPVTVTVFDTPKGA

3D structure

• PDB: 1eu1 Crystal Structure of DMSO Reductase: Redox-linked Changes in Molybdopterin Coordination
• Chain: A
• Resolution: 1.3 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): Y114 W116 D145 S147 T148 S357 Y360
• Catalytic site (residue number reindexed from 1): Y111 W113 D142 S144 T145 S354 Y357
• Enzyme Commision number: 1.7.2.3: trimethylamine-N-oxide reductase.
  1.8.5.3: respiratory dimethylsulfoxide reductase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	GLC	A	M9 W32 D33 K34 I567	M6 W29 D30 K31 I554
BS02	GLC	A	R401 D404 V743 Q750	R388 D391 V730 Q737
BS03	MGD	A	G115 W116 K117 S118 C125 Y146 S147 R326 G432 G433 N434 H438 Q458 D459 F460 D511 A641 H643 H649 S650 Q651 E715 N737	G112 W113 K114 S115 C122 Y143 S144 R323 G419 G420 N421 H425 Q445 D446 F447 D498 A628 H630 H636 S637 Q638 E702 N724
BS04	MGD	A	W116 S147 A185 K190 T191 I194 I220 N221 P222 P240 D243 W322 S323 I324 R326 M327 H359 S642 H643 P644 R647 H649 Q755	W113 S144 A182 K187 T188 I191 I217 N218 P219 P237 D240 W319 S320 I321 R323 M324 H356 S629 H630 P631 R634 H636 Q742
BS05	O	A	Y114 D145 Y146 S147	Y111 D142 Y143 S144

Gene Ontology

Molecular Function

• GO:0009055 electron transfer activity
• GO:0016491 oxidoreductase activity
• GO:0030151 molybdenum ion binding
• GO:0043546 molybdopterin cofactor binding
• GO:0046872 metal ion binding
• GO:0050626 trimethylamine-N-oxide reductase (cytochrome c) activity

Biological Process

• GO:0009061 anaerobic respiration

Cellular Component

• GO:0030288 outer membrane-bounded periplasmic space
• GO:0042597 periplasmic space

External links

• PDB: RCSB:1eu1, PDBe:1eu1, PDBj:1eu1
• PDBsum: 1eu1
• UniProt: Q57366|DSTOR_CERSP Dimethyl sulfoxide/trimethylamine N-oxide reductase (Gene Name=dmsA)