Structure of PDB 1eth Chain A

Receptor sequence
>1ethA (length=448) Species: 9823 (Sus scrofa) [Search protein sequence]
SEVCFPRLGCFSDDAPWAGIVQRPLKILPWSPKDVDTRFLLYTNQNQNNY
QELVADPSTITNSNFRMDRKTRFIIHGFIDKGEEDWLSNICKNLFKVESV
NCICVDWKGGSRTGYTQASQNIRIVGAEVAYFVEVLKSSLGYSPSNVHVI
GHSLGSHAAGEAGRRTNGTIERITGLDPAEPCFQGTPELVRLDPSDAKFV
DVIHTDAAPIIPNLGFGMSQTVGHLDFFPNGGKQMPGCQKNILSQIVDID
GIWEGTRDFVACNHLRSYKYYADSILNPDGFAGFPCDSYNVFTANKCFPC
PSEGCPQMGHYADRFPGKTNGVSQVFYLNTGDASNFARWRYKVSVTLSGK
KVTGHILVSLFGNEGNSRQYEIYKGTLQPDNTHSDEFDSDVEVGDLQKVK
FIWYNVINPTLPRVGASKITVERNDGKVYDFCSQETVREEVLLTLNPC
3D structure
PDB1eth Lipase activation by nonionic detergents. The crystal structure of the porcine lipase-colipase-tetraethylene glycol monooctyl ether complex.
ChainA
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) F78 S153 L154 D177 H264
Catalytic site (residue number reindexed from 1) F78 S153 L154 D177 H264
Enzyme Commision number 3.1.1.3: triacylglycerol lipase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BMA A R164 R165 R164 R165
BS02 CA A E188 R191 D193 D196 E188 R191 D193 D196
BS03 C8E A F216 W253 R257 F216 W253 R257
BS04 C8E A H76 G77 F78 I79 D80 H152 R257 H76 G77 F78 I79 D80 H152 R257
Gene Ontology
Molecular Function
GO:0004806 triacylglycerol lipase activity
GO:0016298 lipase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
GO:0047376 all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity
GO:0052689 carboxylic ester hydrolase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0016042 lipid catabolic process
GO:0042572 retinol metabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space

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Cellular Component
External links
PDB RCSB:1eth, PDBe:1eth, PDBj:1eth
PDBsum1eth
PubMed8663362
UniProtP00591|LIPP_PIG Pancreatic triacylglycerol lipase (Gene Name=PNLIP)

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