Structure of PDB 1esm Chain A

Receptor sequence
>1esmA (length=311) Species: 562 (Escherichia coli) [Search protein sequence]
QTLMTPYLQFDRNQWAALRDSVPMTLSEDEIARLKGINEDLSLEEVAEIY
LPLSRLLNFYISSNLRRQAVLEQFLGTNGQRIPYIISIAGSVAVGKSTTA
RVLQALLSRWPEHRRVELITTDGFLHPNQVLKERGLMKKKGFPESYDMHR
LVKFVSDLKSGVPNVTAPVYSHLIYDVIPDGDKTVVQPDILILEGLNVLQ
SGMDYPHDPHHVFVSDFVDFSIYVDAPEDLLQTWYINRFLKFREGAFTDP
DSYFHNYAKLTKEEAIKTAMTLWKEINWLNLKQNILPTRERASLILTKSA
NHAVEEVRLRK
3D structure
PDB1esm Structural basis for the feedback regulation of Escherichia coli pantothenate kinase by coenzyme A.
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.33: pantothenate kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 COA A G41 I42 V97 K101 S102 R106 K145 Y175 H177 Y180 L201 Y240 R243 F247 F259 G36 I37 V92 K96 S97 R101 K140 Y170 H172 Y175 L196 Y235 R238 F242 F254
Gene Ontology
Molecular Function
GO:0004594 pantothenate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0042803 protein homodimerization activity
GO:0050165 pantetheine kinase activity
Biological Process
GO:0015937 coenzyme A biosynthetic process
GO:0016310 phosphorylation
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:1esm, PDBe:1esm, PDBj:1esm
PDBsum1esm
PubMed10862768
UniProtP0A6I3|COAA_ECOLI Pantothenate kinase (Gene Name=coaA)

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