Structure of PDB 1err Chain A

Receptor sequence
>1errA (length=225) Species: 9606 (Homo sapiens) [Search protein sequence]
ALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVH
MINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAP
NLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNS
GVYEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRH
MSNKGMEHLYSMPLYDLLLEMLDAH
3D structure
PDB1err Molecular basis of agonism and antagonism in the oestrogen receptor.
ChainA
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 RAL A L346 T347 A350 D351 E353 L354 W383 L387 F404 M421 I424 H524 L525 L40 T41 A44 D45 E47 L48 W77 L81 F98 M115 I118 H208 L209 PDBbind-CN: -logKd/Ki=8.11,IC50=7.7nM
BindingDB: IC50=1.8nM,EC50=2.4nM,Ki=0.37nM
External links
PDB RCSB:1err, PDBe:1err, PDBj:1err
PDBsum1err
PubMed9338790
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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