Structure of PDB 1emj Chain A

Receptor sequence
>1emjA (length=223) Species: 9606 (Homo sapiens) [Search protein sequence]
MEFFGESWKKHLSGEFGKPYFIKLMGFVAEERKHYTVYPPPHQVFTWTQM
CDIKDVKVVILGQDPYHGPNQAHGLCFSVQRPVPPPPSLENIYKELSTDI
EDFVHPGHGDLSGWAKQGVLLLNAVLTVRAHQANSHKERGWEQFTDAVVS
WLNQNSNGLVFLLWGSYAQKKGSAIDRKRHHVLQTAHPSPLSVYRGFFGC
RHFSKTNELLQKSGKKPIDWKEL
3D structure
PDB1emj Uracil-DNA glycosylase-DNA substrate and product structures: conformational strain promotes catalytic efficiency by coupled stereoelectronic effects.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.2.27: uracil-DNA glycosylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A D145 Y147 H148 P168 S169 G246 S247 H268 S270 P271 L272 S273 R276 D64 Y66 H67 P87 S88 G165 S166 H187 S189 P190 L191 S192 R195
BS02 dna A L272 Y275 L191 Y194
BS03 URA A G143 Q144 D145 Y147 C157 F158 N204 H268 G62 Q63 D64 Y66 C76 F77 N123 H187
Gene Ontology
Molecular Function
GO:0004844 uracil DNA N-glycosylase activity
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
Biological Process
GO:0006281 DNA repair
GO:0006284 base-excision repair

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Molecular Function
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Biological Process
External links
PDB RCSB:1emj, PDBe:1emj, PDBj:1emj
PDBsum1emj
PubMed10805771
UniProtP13051|UNG_HUMAN Uracil-DNA glycosylase (Gene Name=UNG)

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