Structure of PDB 1e98 Chain A

Receptor sequence
>1e98A (length=210) Species: 9606 (Homo sapiens) [Search protein sequence]
ARRGALIVLEGVDRAGKSTQSRKLVEALCAAGHRAELLRFPERSTEIGKL
LSSYLQKKSDVEDHSVHLLFSANRWEQVPLIKEKLSQGVTLVVDRYAFSG
VAFTGAKENFSLDWCKQPDVGLPKPDLVLFLQLQLADAAKRGAFGHERYE
NGAFQERALRCFHQLMKDTTLNWKMVDASKRIEAVHEEIRVLSEDAIRTA
TEKPLGELWK
3D structure
PDB1e98 Potentiating Azt Activation: Structures of Wildtype and Mutant Human Thymidylate Kinase Suggest Reasons for the Mutants' Improved Kinetics with the HIV Prodrug Metabolite Aztmp
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.4.9: dTMP kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A G18 K19 S20 T21 R143 I184 G16 K17 S18 T19 R141 I182
BS02 ATM A F42 L57 F72 R76 R97 G102 F105 Y151 F40 L55 F70 R74 R95 G100 F103 Y149
Gene Ontology
Molecular Function
GO:0004550 nucleoside diphosphate kinase activity
GO:0004798 thymidylate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
Biological Process
GO:0006227 dUDP biosynthetic process
GO:0006233 dTDP biosynthetic process
GO:0006235 dTTP biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0016310 phosphorylation
GO:0043627 response to estrogen
GO:0045445 myoblast differentiation
GO:0046105 thymidine biosynthetic process
GO:0046686 response to cadmium ion
GO:0046940 nucleoside monophosphate phosphorylation
GO:0071363 cellular response to growth factor stimulus
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:1e98, PDBe:1e98, PDBj:1e98
PDBsum1e98
PubMed11071809
UniProtP23919|KTHY_HUMAN Thymidylate kinase (Gene Name=DTYMK)

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